Royal Air Force Typhoon FGR4s have operated alongside French aircraft in a coordinated attack targeting an hidden munitions depot in Syria operated by the IS group, as stated by the UK's MoD.
The site, located using surveillance, was assessed as housing weapons and explosive materials, the statement said, and was located in mountains just above the historic site of Palmyra in Syria's central region.
"Our aircraft employed Paveway IV guided bombs to hit a number of entry passages leading to the site... initial indications indicate the strike was effective," officials stated.
There was no sign of any harm to civilians in the operation on Saturday evening and all the aircraft returned safely, the defence officials confirmed.
The Typhoon FGR4s were backed up by a Voyager tanker plane.
IS - referred to as the so-called Islamic State - enforced jihadist rule over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This operation underscores our UK leadership, and resolve to stand shoulder to shoulder with allied nations, to eliminate any resurgence of Daesh and their harmful and extremist ideologies in the area," UK Defence Secretary the Defence Secretary stated.
British military aircraft have performed surveillance missions over Syria to "deter any attempted comeback" of Islamic State following its routing at the climactic battle in Baghuz in 2019, the ministry said.
"I extend gratitude to all the members of the UK armed forces participating in this operation for their skill and their bravery," Healey said. "They were part of numerous British troops on duty over Christmas and New Year. This action, to eliminate terrorist threats who pose a risk to our way of life, highlights how British military are always on standby, continuously, ensuring Britain's security domestically and strong abroad."
During December, the US military conducted what it described as a "large-scale strike" on Islamic State objectives in the country, subsequent to an attack claimed the lives of two US servicemembers and a civilian linguist in the Palmyra area.
The UN reports Daesh still has between 5,000 and 7,000 fighters in Iraq and Syria.
